Small Business Innovation Research · Small Business Technology Transfer
SBIR & STTR awards
49,834 awards worth $23.79B to 12,374 companies since 1983 match these filters. Phase I tests an idea (usually a few hundred thousand dollars); Phase II builds it (often $1M or more).
Open now (18)
- The National Institute of Standards and Technology (NIST) Small Business Innovation Research (SBIR) Program SupportNATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY · Sources Sought · due 2026-10-13 · SAM.gov · notice ↗
- America’s Seed Fund: Planting Seeds for Success Under the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) ProgramsGENERAL SERVICES ADMINISTRATION · Special Notice · due 2026-10-22 · SAM.gov · notice ↗
- A--SBIR FY26 Phase I Broad Agency AnnouncementENVIRONMENTAL PROTECTION AGENCY · Solicitation · due 2026-11-08 · SAM.gov · notice ↗
- NASA SBIR/STTR FY 2026-2027 Broad Agency Announcement (BAA)NATIONAL AERONAUTICS AND SPACE ADMINISTRATION · Presolicitation · due 2027-09-30 · SAM.gov · notice ↗
- NASA SBIR/STTR FY 2026-2027 Broad Agency Announcement (BAA)NATIONAL AERONAUTICS AND SPACE ADMINISTRATION · Presolicitation · due 2027-09-30 · SAM.gov · notice ↗
- NSF Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs: A Pilot Emphasis on Scientific Instrumentation ↗U.S. National Science Foundation · closes 2026-11-04 · Grants.gov 26-511
- Small Business Innovation Research and Small Business Technology Transfer Programs Phase II ↗National Institute of Food and Agriculture · closes 2026-11-17 · Grants.gov USDA-NIFA-SBIR-012221
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) ↗National Institutes of Health · closes 2027-04-05 · Grants.gov PA-27-102
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) ↗National Institutes of Health · closes 2027-04-05 · Grants.gov PA-27-100
- Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required) ↗National Institutes of Health · closes 2027-05-07 · Grants.gov PAR-26-001
- SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) ↗National Institutes of Health · closes 2029-04-05 · Grants.gov PAR-27-098
- NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) ↗National Institutes of Health · closes 2029-04-05 · Grants.gov PA-27-101
- Forecast to Publish a Notice of Funding Opportunity for SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional) ↗National Institutes of Health · forecast · Grants.gov FOR-CA-25-086
- NIEHS Worker Training Program’s SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) ↗National Institutes of Health · forecast · Grants.gov TEMP-30794
- SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Required) ↗National Institutes of Health · forecast · Grants.gov FOR-OD-26-007
- Small Business Innovation Research (SBIR) program, Phase I ↗Administration for Community Living · forecast · Grants.gov HHS-2027-ACL-NIDILRR-BISA-0308
- Small Business Innovation Research Program (SBIR) Phase II ↗Administration for Community Living · forecast · Grants.gov HHS-2027-ACL-NIDILRR-BISB-0309
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Required) ↗National Institutes of Health · forecast · Grants.gov FOR-OD-26-004
Solicitations with SBIR or STTR in the title, from the nightly SAM.gov and Grants.gov loads. Each agency lists its topics in its own portal.
Awards by year
| Year | Phase I | Phase II | Amount |
|---|---|---|---|
| 2025 | 662 | 464 | $752.07M |
| 2024 | 732 | 493 | $1.23B |
| 2023 | 856 | 537 | $1.47B |
| 2022 | 868 | 512 | $1.31B |
| 2021 | 867 | 480 | $1.24B |
| 2020 | 856 | 541 | $1.31B |
| 2019 | 1,158 | 483 | $1.21B |
| 2018 | 1,152 | 417 | $1.03B |
| 2017 | 918 | 490 | $1.05B |
| 2016 | 898 | 452 | $950.84M |
| 2015 | 833 | 404 | $824.15M |
| 2014 | 972 | 382 | $823.22M |
The latest year fills in over months: agencies report awards to SBIR.gov with a lag.
Companies with the most SBIR/STTR money
- Sanaria Inc. Maryland · 59 awards (29 Phase II) · $98.18M · last 2024
- Radiation Monitoring Devices, Inc. Massachusetts · 263 awards (95 Phase II) · $93.94M · last 2025
- Physical Sciences Inc. Massachusetts · 193 awards (60 Phase II) · $87.07M · last 2025
- Epicypher, Inc. North Carolina · 64 awards (33 Phase II) · $79.15M · last 2025
- Microbiotix, Inc. Massachusetts · 88 awards (18 Phase II) · $78.71M · last 2025
- Angion Biomedica Corp. California · 77 awards (27 Phase II) · $60.96M · last 2019
- Advanced Medical Electronics Corp Minnesota · 132 awards (43 Phase II) · $60.94M · last 2024
- Lynntech Inc. Texas · 206 awards (41 Phase II) · $60.80M · last 2025
- Affinergy, LLC North Carolina · 75 awards (25 Phase II) · $59.80M · last 2023
- Biosensics LLC Massachusetts · 49 awards (25 Phase II) · $56.78M · last 2025
- Giner Inc Massachusetts · 119 awards (40 Phase II) · $54.38M · last 2025
- Creare LLC New Hampshire · 141 awards (53 Phase II) · $54.13M · last 2025
- Barron Associates, Inc. Virginia · 87 awards (32 Phase II) · $51.13M · last 2025
- L2 Diagnostics LLC Connecticut · 94 awards (18 Phase II) · $49.70M · last 2025
- Celdara Medical, LLC New Hampshire · 52 awards (18 Phase II) · $49.30M · last 2025
Latest matching awards
| Award | Company | Agency | Phase | Amount | Date |
|---|---|---|---|---|---|
| Improved Treatment Options for Vertebral Compression Fractures in Elderly Patients Using Minimally Invasive, Image-Guided Delivery of a Regenerative Bone Adhesive · topic NIA | Revbio, Inc. · Massachusetts | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $2.04M | 2025-09-30 |
| Lateral Flow-Electrochemiluminescent (LF-ECL) Test Strips and Portable Reader for Ultrasensitive Foodborne Pathogen Detection · topic NCEZID | Nanohmics Inc · Texas | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase II | $1.05M | 2025-09-30 |
| Developing and Evaluating Visual, Auditory, and Tactile and Text Digital Thematic Map Viewer to Provide Blind and Low Vision Individuals Full Access to Thematic Maps for the First Time · topic NEI | XR Navigation Inc · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $1.01M | 2025-09-30 |
| Air Plasma Sterilization Device with Plasma-in-Lumen Technology · topic FDA | Advanced Cooling Technologies Inc · Pennsylvania | Department of Health and Human Services · Food and Drug Administration | SBIR Phase II | $999.9K | 2025-09-30 |
| A novel remote blood separation device for at-home plasma collection for HIV-1 testing · topic NCHHSTP | Lo Biosciences, Inc · Maryland | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase II | $994.7K | 2025-09-30 |
| Auto-calibrating, Air Quality Monitoring System · topic NIOSH | Seacoast Science, Inc. · California | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase II | $541.6K | 2025-09-30 |
| IND-enabling studies of KTX-1161, a novel NRF2 activator for corneal endothelial disease · topic NEI | Kuria Therapeutics, Inc · Arkansas | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $399.9K | 2025-09-30 |
| Indigo Eyewear for Treating Myopia Progression · topic NEI | Electric Indigo · Alabama | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $356.8K | 2025-09-30 |
| "Harnessing Technology for Safer Food Imports: Training and Certifying Global Producers for U.S. Market Access" · topic FDA | Food Enterprise Solutions, LLC · Virginia | Department of Health and Human Services · Food and Drug Administration | SBIR Phase I | $349.9K | 2025-09-30 |
| First in Class Mitochondrially targeted antioxidants with transcriptional modulator capabilities and their implication in the diseases of the eye · topic NEI | N'Waii Inc. · Illinois | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $348.8K | 2025-09-30 |
| Ultra-Rapid Optical Platform for Antimicrobial Susceptibility Testing (AST) ofPulmonary Non-Tuberculous Mycobacterial (NTM) Infections · topic GHC | SKM Instruments, LLC · Wyoming | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase I | $306.9K | 2025-09-30 |
| Advancing Probe Technology for Ultrasensitive RNA Imaging via Hybridization Chain Reaction · topic 400 | Molecular Instruments, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $306.8K | 2025-09-30 |
| Wearable Heat Related Injury Risk Analysis (WHERA) system Resubmission · topic NIOSH | Chromologic LLC · California | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase I | $306.5K | 2025-09-30 |
| Novel light source development for robust multi-MHz retinal OCT · topic NEI | Bluebird Photonics, Inc · Massachusetts | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $305.9K | 2025-09-30 |
| Topical Ophthalmic Treatment for Neovascular Age-related Macular Degeneration (nAMD) · topic NEI | NeoVascularX, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $305.3K | 2025-09-30 |
| METAVEST: Advanced Biomimetic Personal Cooling for Enhancing Heat Safety Among High-Risk Workers · topic NIOSH | Hawai'I Innovation Inc. · Hawaii | Department of Health and Human Services · Centers for Disease Control and Prevention | SBIR Phase I | $302.4K | 2025-09-30 |
| Addressing Structural Disorder and Conformational Heterogeneity in Modern Therapeutic Modalities: A Unified X-ray/Cryo-EM QM/MM Ensemble Refinement Toolkit with Enhanced Density-Driven MD · topic 400 | Quantumbio Inc · Pennsylvania | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $254.2K | 2025-09-30 |
| Innovative Amperometric Gas Sensors for Monitoring Post-Harvest Food Quality and Safety · topic FDA | Interlink Electronics, Inc · California | Department of Health and Human Services · Food and Drug Administration | SBIR Phase I | $200.0K | 2025-09-30 |
| IND-Enabling Development of HIV Maturation Inhibitors Formulated for use as either Oral or Long-Acting Parenterally Administered Agents · topic NIAID | DFH Pharma, Inc · Maryland | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $986.9K | 2025-09-26 |
| Detecting Absence Seizures Using Hyperventilation In a Home Environment · topic 600 | Eysz, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $545.2K | 2025-09-26 |
| Engineered Memory T cells as a Platform to Treat Enzymopathies · topic NIAID | Kommodo Holdings Corp. · Minnesota | Department of Health and Human Services · National Institutes of Health | STTR Phase I | $304.8K | 2025-09-26 |
| SBIR TOPIC 111, PHASE II: A COMPACT PORTABLE MEDICAL OXYGEN GENERATOR · topic 111 | Tda Research, Inc. · Colorado | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $2.00M | 2025-09-25 |
| Ultra-high sensitivity, high spatial resolution single photon emission tomography using mechanical flux manipulation · topic 101 | Quant, Inc. · Washington | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $1.84M | 2025-09-25 |
| CEACAM5-targeted activation of potent chemotherapeutics via bioorthogonal click chemistry · topic NCI | Shasqi, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $1.09M | 2025-09-25 |
| Device Automation of an FDA-cleared CD-Microfluidic Platform for Rapid Tissue Microsizing · topic 400 | Syntr Health Technologies, Inc · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $1.05M | 2025-09-25 |
| Multidimensional antibody engineering to enhance the potency and breadth of a betacoronavirus medical countermeasure · topic NIAID | Eitr Biologics, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $1.00M | 2025-09-25 |
| Development of Cobinamide as a Cyanide Antidote: Completion of pre-IND Studies · topic NIAID | Mesa Science Associates, Inc. · Maryland | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $980.4K | 2025-09-25 |
| emuLAAte: atraumatic patient-specific stroke prevention technology · topic NHLBI | Spheric Bio Inc · Delaware | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $598.6K | 2025-09-25 |
| Reducing infections and blockage associated with long-term implantation of ventriculoperitoneal and related shunts · topic 106 | Wynnvision LLC · Virginia | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $306.3K | 2025-09-25 |
| Home-based plasma self-collection device for remote diagnosis and monitoring of AD-associated biomarkers · topic NIA | Lo Biosciences, Inc · Maryland | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $305.6K | 2025-09-25 |
| Broad-spectrum, multivalent platform for pan-influenza vaccine · topic NIAID | VIVA Viral Vaccines, Inc · New York | Department of Health and Human Services · National Institutes of Health | STTR Phase I | $300.0K | 2025-09-25 |
| BLiPS: Biocompatible Liver in Pigs · topic 300 | Renovate Biosciences, Inc. · Maryland | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $292.1K | 2025-09-25 |
| Systemic Transplantation of MyoPAXon: IND Enabling Studies for the Treatment of DMD · topic NIAMS | Myogenica Inc. · Minnesota | Department of Health and Human Services · National Institutes of Health | STTR Phase II | $1.27M | 2025-09-24 |
| Engagement and clinical impact of the Teleo virtual therapy platform in clinical settings · topic 104 | Mainsquare Co · California | Department of Health and Human Services · National Institutes of Health | STTR Phase II | $1.24M | 2025-09-24 |
| Liquid Immunotherapeutic Fiducial Eluter (LIFE) Gel for Cervical Cancer · topic 102 | Nanocan Therapeutics Corporation · New Jersey | Department of Health and Human Services · National Institutes of Health | STTR Phase II | $998.8K | 2025-09-24 |
| Development of highly potent human monoclonal for RSV immunoprophylaxis · topic NIAID | Mapp Biopharmaceutical, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase II | $993.4K | 2025-09-24 |
| Engineered Monothiol Thioredoxin for Treatment of Radiation Induced Lung Injury · topic NHLBI | Orpro Therapeutics Inc · California | Department of Health and Human Services · National Institutes of Health | STTR Phase I | $509.0K | 2025-09-24 |
| Development and Validation of a Compliant Reversible Actuator and Detector Leveraging Electrophysiology for Organoids (Organoid-CRADLE) · topic 101 | Neurolux, Inc. · Illinois | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $499.8K | 2025-09-24 |
| Novel multivalent PSMA-targeted taxane-conjugates for bone metastases in prostate cancer · topic 102 | Paramita Therapeutics, Inc. · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $353.0K | 2025-09-24 |
| Continuous Non-Invasive Blood Pressure during Sleep as a Cardiovascular Biomarker · topic NHLBI | Vena Vitals Inc · California | Department of Health and Human Services · National Institutes of Health | SBIR Phase I | $306.9K | 2025-09-24 |
Source: SBIR.gov award data (SBA) ↗, awards through 2026-08-28. Amounts are as agencies report them to SBA. SBIR/STTR contracts also appear in USAspending as ordinary awards; grants (NIH, NSF, DOE) appear as assistance. Open topics are posted by each agency; see Opportunities for contract notices.